Functional connectivity of the visual cortex differentiates anxiety comorbidity from episodic migraineurs without aura

Abstract Background Migraine is a common neurological disease that often accompanied by psychiatric comorbidities. However, the relationship between abnormal brain function and comorbidities in migraine patients remains largely unclear. Therefore, present study sought to explore correlations resting-state functional deficits without aura (MwoA) patients. Methods Resting-state magnetic resonance images were obtained. In addition, amplitude of low-frequency fluctuation (ALFF) regional homogeneity (ReHo) values Thereafter abnormalities MwoA with anxiety (MwoA-A MwoA-OA) chosen as seeds conduct connectivity (FC) analysis. Results Compared healthy controls (HCs), MwoA-A MwoA-OA had ALFF ReHo right lingual gyrus (LG). They also FC LG ipsilateral superior frontal (SFG) middle cingulate cortex (MCC). Additionally, showed higher left posterior intraparietal sulcus (pIPS) pIPS primary visual cortex, compared Moreover, an increase cortex/precuneus (PCC/PCUN), (MFG) inferior temporal (ITG) relative HCs. Furthermore, positively correlated scores The LG-related FCs PCC/PCUN, MFG ITG negatively associated frequency headaches Conclusions This identified along other core networks differentiating comorbidity from MwoA. may therefore enhance understanding neuropsychological basis provide novel insights help discovery new marks or even treatment targets.